| Abnormal chromosome is on the right in each pair |
Abnormality
(major breakpoint or breakpoint range) |
Disorder |
Genes Involved
(Linked to NCBI)
|
|
|
|
t(1;3)(p36.1;q21) |
AML |
PRDM16
RPN1
|
|
|
|
der(1;7)(q10;p10) |
MDS |
|
|
|
|
t(1;11)(p32;q23) |
ALL, MDS, AML |
EPS15
MLL
|
|
|
|
t(1;14)(p32-34;q11.2)
|
ALL |
TAL1
TRA@
|
 |
 |
der(16)t(1;16)(q21;q13) |
Wilms Tumor |
|
|
 *
|
|
t(1;19)(q23;p13.3) |
ALL |
PBX1
TCF3 (E2A)
|
|
|
|
t(2;8)(p12;q24.1) |
ALL,
Burkitt's Lymphoma
(variant of t(8;14)
|
IGK@
(c-)MYC
|
|
|
|
t(2;13)(q35;q14)
|
Alveolar rhabdomyosarcoma |
PAX3
FOXO1
|
|
|
|
t(3;3)(q21;q26.2)
|
AML, MDS |
RPN1
EVI1
|
|
|
|
t(3;11)(p21;q23) |
ALL-Biphenotypic (rare) |
EEFSEC
MLL
|
|
|
|
t(3;14)(q27;q32) |
Diffuse lg. cell or follicular B-NonHodgkins Lymphoma |
BCL6
IGH@
|
|
|
|
t(3;21)(q26.2;q22) |
AML, MDS |
EVI1
RUNX1 (AML1)
|
|
|
|
t(3;22)(q27;q11.2) |
Diffuse lg. cell or follicular B-NonHodgkins Lymphoma |
BCL6
IGL@
|
 |
|
t(4;11)(q21;p15) |
T-ALL |
RAP1GDSI
NUP98
|
|
|
|
t(4;11)(q21;q23) |
ALL |
AFF1 (AF4)
MLL
|
|
|
 |
t(5;12)(q31;p13) |
AML, MDS, RAEB, Acute eosinophilic leukemia (rare) |
ACSL6
ETV6 (TEL)
|
|
|
|
t(6;9)(p23;q34) |
AML, MDS |
DEK
NUP214 (CAN)
|
|
|
|
t(6;11)(q27;q23) |
AML |
MLLT4 (AF6)
MLL
|
|
|
|
t(7;11)(p15;p15) |
AML |
HOXA9
NUP98
|
|
 (14's unavailable)*
|
|
t(8;14)(q24.1;q11.2) |
ALL (T-lineage) |
(c-)MYC
TRA@
|
|
|
|
t(8;14)(q24.1;q32) |
ALL, Burkitt's lymphoma |
(c-)MYC
IGH@
|
 |
|
t(8;16)(p11.2;p13.3) |
AML, t-AML |
KAT6A (MOZ)
CREBBP
|
|
|
|
t(8;21)(q22;q22) |
AML |
RUNXT1 (ETO)
RUNX1 (AML1)
|
|
|
|
t(8;22)(p11.2;q11.2) |
CML-like (rare) |
FGFR1
BCR
|
|
|
|
t(8;22)(q24.1;q11.2) |
AML, Burkitt's lymphoma (variant of t(8;14) |
(c-)MYC
IGL@
|
| *in some cases, derivative chromosomes had to be used from unbalanced translocations |
go to translocations pg 2 |
