Chronic myeloid/granulocytic leukemia (CML/CGL) is a stem cell malignancy affecting all cells of the marrow, including granulocytes, erythroid cells, megakaryocytes, and B lymphoid cells. A high blood white cell count with immature and mature granulocytes is a characteristic feature. Thrombocytosis, anemia, and splenomegaly are often present. Initially symptoms may be mild, but without aggressive intervention (bone marrow transplant) the disease ends in terminal acute leukemia (blast crisis or blast transformation) with replacement of marrow by myeloblasts in approximately two-thirds of cases or lymphoblasts in approximately one-third of cases). Transformation from the chronic phase to an accelerated phase may be identified by myelofibrosis, increased basophilia, marked anemia, thrombocytopenia, or karyotypic evolution. CML can be seen at any age but is more common in adults.
|chromosome 1 abnormalities||multiple myeloma|
|14q32 rearrangements||hairy cell leukemia, Sezary's syndrome, B-CLL, B-cell prolymphocytic leukemia (B-PLL), multiple myeloma|
|del(6q)||hairy cell leukemia, Sezary's synd., B-CLL|
|t(9;14)(p13;q32)||CLL, multiple myeloma|
|t(11;14)(q13;q32)||B-PLL, multiple myeloma, B-CLL|
|t(14;14)(q11;q32)||T-lineage, adult T-Cell leukemia (ATL)|
University of Wisconsin Cytogenetic Services