Chronic myeloproliferative disorders
Chronic myeloproliferative disorders (CMPD) include CML, polycythemia vera (PCV), myelofibrosis with myeloid metaplasia (MMM), and essential thrombocythemia (ET). Each is a clonal proliferation of a pluripotent stem cell that can differentiate along granulocytic, erythroid, and megakaryocytic lines. Each has a chronic course that often terminates as acute leukemia or myelofibrosis. CMPD are more common in adults.
|del(13q) interstital or terminal||PCV,MMM|
|del(20)(q11.2) or (q11.2q13.1)||PCV,MMM|
University of Wisconsin Cytogenetic Services