Langer-Giedion Syndrome is an extremely rare genetic, multi-system disorder that belongs to the group of diseases known as Ectodermal Dysplasias. Langer-Giedion Syndrome is characterized by fine, thin hair; unusual facial features; progressive growth retardation resulting in short stature; abnormally short fingers and toes (brachydactyly); "cone-shaped" formation of the "growing ends" of certain bones; development of multiple bony growths (exostoses) projecting outward from the surfaces of various bones of the body; and/or additional abnormalities. [from the Langer-Giedion Syndrome Association]

Chromosome region: 8q24.11-q24.13

Also known as: (tricho-rhino-phalangeal syndrome (TRPS) type II)

Links to Langer-Giedion sites:

• Online Mendelian Inheritance in Man database information
• Langer-Giedion Syndrome Association
• National Foundation for Ectodermal Dysplasias
• Langer-Giedion sites listed by Yahoo