Deletion 1p, FISH, Glial neoplasia

Deletion 1p, FISH, Glial neoplasia
WSLH Department: Cytogenetics
WSLH Test Code:886F5
CPT Code: 
Price: 
Includes:FISH analysis of 200 cells for copy number of chromosome 1p compared to copy number of chromosome 1q
Methodology:**(CPT Codes: 88271x2, 88275)** Fluorescence in situ hybridization performed on interphase nuclei from paraffin embedded tissue using DNA probes (LSI 1p36/LSI 1q25; Vysis, Inc) covering the region including the TP73 and EGFL3 genes in 1p36 and probes covering the region including the ABL2 and ANGPTL1 genes in 1q25 as an internal control
Availability:Monday-Friday 7:45 AM - 4:30 PM, Saturday 7:45 AM - 12:00 PM
Turn-around Time:Approximately 5-6 days. (Reports are issued Monday-Friday 7:45 AM - 4:30 PM)
Recommended Uses:Detection of relative loss of the short arm of chromosome 1. Aid in diagnosis of glial neoplasia including astrocytoma and oligodendroglioma.
Contraindications: 
Specimen Requirements:Paraffin embedded tissue: Five 4-micron sections on immunohistochemistry slides, the middle section stained with H&E.
Collection Kit/Container: 
Patient Preparation: 
Collection Instructions:FFPE tissue: Tissue specimen should be fixed in 10% neutral buffered formalin for 6-48 hours.
Specimen Handling and Transport:Store and transport specimens at room temperature.
Unacceptable Conditions:FFPE tissue specimen must not be de-calcified.
Requisition Form:Cytogenetics Lab Neoplasia Diagnosis Form #132
Required Information:Laboratory regulations require the following minimum information to be provided on the requisition form for a specimen to be accepted for testing: Patient name or unique identifier; date and time of collection, patient date of birth and sex, specimen type/site of collection, test request(s), reason for referral, clinician name and UPIN/NPI, and address for reporting results. Please be certain that name/identifier on the form matches that on the specimen label.
Results include:Ratio of 1p36 to 1q25 signals. Deletion 1p detected/not detected
Limitations: 
Additional Tests Recommended:Test 886F6 for detection of deletion of 19q.
Additional Comments: 
Additional Tests Performed: 

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