THAT’S SICK: Headlines from the Public Health Laboratory Bench

baby-feet-blue-blanketThe Wisconsin Newborn Screening Laboratory is featured in “THAT’S SICK! Headlines from the Public Health Laboratory Bench”, an online virtual open house for students interested in careers in public health laboratory science.

THAT’S SICK includes modules that let visitors explore the role of the laboratorian in areas of critical importance to the health of the public, including foodborne outbreaks, vectorborne diseases, infectious diseases, emergency preparedness, newborn screening, and environmental health.

The project was developed by members of the Emerging Leader Program, sponsored by the Association of Public Health Laboratories.

Environmental Monitoring and Trends Seminar — March 3, 2015

Scientists and staff from the WI State Laboratory of Hygiene (WSLH) and WI Department of Natural Resources (DNR)  provided insight and updates about environmental monitoring and trends at a seminar held on March 3, 2015, at the WSLH’s Agriculture Drive facility in Madison.

The seminar was live-streamed on the web on March 3rd. Links to the archived webcasts are below.

 

Archived webcasts

You will need to access the archived webcasts using Internet Explorer. You will also need Microsoft Silverlight installed on your computer.

A.M. sessions webcast (NOTE: webcast starts at 04:41): https://slhstream2.ad.slh.wisc.edu/Mediasite/Play/f3b48a94a6744bd79267f5a2f2a78ce61d

P.M. sessions webcast (NOTE: webcast starts at 01:14): https://slhstream2.ad.slh.wisc.edu/Mediasite/Play/8bf5d354becd4b93916bd842a0b1afed1d

 

 

Webcast Session / Start Time
Topic Speaker
AM / 07:29 Well Assessment Sharon Long (WSLH)
AM / 25:00 Satellite Images and Monitoring Daniela Gurlin (DNR)
AM / 47:16 Radiochemistry Susan Percy (WSLH)
AM / 01:10:06 2, 4-D Study – Jim Kreitlow (DNR), Camille Danielson & Curtis Hedman (WSLH)
AM / 01:32:21 Cryptosporidium in Soil Zach Zopp (UW-Madison)
AM / 01:52:24 Particle Size Distributions Bill Selbig (USGS)
PM / 01:14 Workload TAT at WSLH Dave Webb (WSLH)
PM / 08:53 Eagle Trend Data Paul Rasmussen (DNR)
PM / 17:37 Future Wildlife Monitoring Sean Strom (DNR)
PM / 30:29 New Multi-Collector ICPMS Capabilities Pat Gorski (WSLH)
PM / 37:08 Microbial Source Tracking (MST) Jamie Stietz (WSLH)
PM / 47:19 Groundwater Dave Johnson (DNR)
PM / 52:55 Endocrine Disruptors Jocelyn Hemming (WSLH)
PM / 01:02:39 Great Lakes Fish Monitoring Candy Schrank (DNR)
PM / 01:09:23 Hexavalent Chromium Pat Gorski (WSLH)
PM / 01:15:44 Arsenic and NR812 DeWayne Kennedy-Parker (WSLH)

 

“Fightin’ Bob” La Follette and Food Poisoning

U.S. Senator Robert La Follette, Sr. Photo: Library of Congress

Sen. Robert La Follette, Sr. Photo: Library of Congress

The mystery surrounding U.S. Senator Robert “Fightin’ Bob” La Follette’s extreme gastrointestinal illness during his May 30, 1908 filibuster is explored in the latest issue of Madison magazine.

Reporter Adam Schrager looks at the historical records and talks to experts to determine whether La Follette was intentionally “drugged” as the Wisconsin senator claimed in letters to family back home, or was he merely a victim of the impact of hot Washington D.C. temperatures on the eggnog he was drinking for sustenance during his 18-hours-plus talking filibuster.

WSLH Foodborne Disease Program Manager and Communicable Disease Supervisor Tim Monson weighs in on the food poisoning angle.

Madison magazine story link

Wisconsin Worker Injury Rate Declines in 2013

According to estimates from the U.S. Bureau of Labor Statistics’ Survey of Occupational Injuries and Illnesses (SOII), Wisconsin’s overall incidence rate of nonfatal occupational injuries and illnesses fell slightly from 4.1 cases per 100 equivalent full-time workers in 2012 to 4.0 cases in 2013.

Nationally, the total injury and illness case rate per 100 full-time workers fell from 3.7 in 2012 to 3.5 in 2013. In surrounding Midwestern states (IA, IL, IN, MI, MN, NE, OH), Iowa had the highest total recordable case rate of 4.8 cases per 100 fulltime workers while Ohio had the lowest rate of 3.0.

SOII is the largest work injury data collection conducted nationwide. The Wisconsin SOII program collects data from a representative sample of 6,000 establishments in both the private and public sector.

 

 Key Findings
  •  There were an estimated 85,200 total injuries and illnesses in Wisconsin workers, with 23,200 (27%) requiring time off due to injury. That number is slightly down from the estimated 23,600 cases requiring time off work in 2012.
  • Private industry total incident rates remained unchanged at 4.0 cases per 100 fulltime workers, while local government rates dropped from 5.2 in 2012 to 4.9 in 2013, and state government rates increased from 3.2 to 3.6 cases.
  • The leading cause of injury requiring days away from work was sprains, strains, and tears, at 38.2% of the 23,200 cases, a decrease from 40% of cases with time off work in 2012.
  • The highest rate of workers with time off due to injury was among establishments with 50-249 employees at 5.0 cases per 100 full-time workers. Employers with 250-999 employees were second-highest, with a rate of 4.3 cases per 100 full-time workers.
  • The median number of days away from work across all industries in Wisconsin was 7. This is lower than the national median of 8 days away from work.
Survey Background and Wisconsin’s BLS/OSH Program

The annual Survey of Occupational Injuries and Illnesses has been conducted nationwide since 1973. The Wisconsin State Laboratory of Hygiene’s (WSLH) Bureau of Labor Statistics/Occupational Safety and Health Statistics Unit has a cooperative agreement with the U.S. Bureau of Labor Statistics to conduct their Survey of Occupational Injuries and Illnesses and Census of Fatal Occupational Injuries in Wisconsin. The WSLH, a part of the University of Wisconsin-Madison, is the state’s public, environmental and occupational health laboratory.

 

ALL WISCONSIN 2013Wisconsin occupational injury profile tables and graphics

Revised Newborn Screening Cards

baby-feet-blue-blanketAs part of the Wisconsin Newborn Screening Program’s (NBS) continuous quality improvement efforts, the NBS collection card forms have been revised so the screening status of every Wisconsin baby can be reported.

The new NBS collection cards will be available on February 16.

If you would like to exchange your current cards for the revised ones, please contact Dr. Mei Baker at the Wisconsin Newborn Screening Laboratory (608-890-1796 or mwbaker@wisc.edu).

icon-pdf   DHS-WSLH letter

icon-pdf   Image of revised Newborn Screening Collection Card Form

icon-pdf   How to complete the Newborn Screening Collection Card Form (Updated 02/04/2015)

 

 

Air Pollution’s Impact on Lung Transplant Patients

lung xray_CDC PHILThe old saying “you are what you eat” may be joined by a new variation – “you are what you breathe” – due to an innovative research collaboration between an engineer and a transplant surgeon.

Jamie Schauer, University of Wisconsin-Madison professor of civil and environmental engineering and director of the Wisconsin State Laboratory of Hygiene’s air chemistry program, has teamed up with UW-Madison transplant surgeon and Assistant Professor Joshua Mezrich to investigate how pollution impacts patients after a lung transplant.

Their work is an example of how Schauer believes environmental engineers and medical professionals can work together to better understand possible links between air pollution and health problems in people.

Schauer and Mezrich’s recent work was profiled by the UW-Madison College of Engineering.

They also just received a $1.8 million grant from the National Institutes of Health to continue their research.

The analysis of air samples for this research is performed at the Wisconsin State Laboratory of Hygiene.

Flu, Drugs and the Taj Mahal — WSLH Research in the News

Flu in schoolchildren, pharmaceuticals in Lake Michigan, and air pollution darkening the white marble of the Taj Mahal. While these might seem like completely random topics they all have something in common – Wisconsin State Laboratory of Hygiene (WSLH) scientists and testing technology.

As part of the University of Wisconsin-Madison, research is one of the core parts of the WSLH’s mission. Recently three research projects in which WSLH scientists have collaborated received media attention.

 

ORCHARDS school flu study

 

girl coughingThis CDC-funded University of Wisconsin-Madison study focuses on schoolchildren in the Oregon, WI school district and combines rapid testing at a UW clinic lab, confirmatory PCR testing at the WI State Laboratory of Hygiene Communicable Disease Division, and epidemiology with the goal of better understanding how the flu and other respiratory viruses can spread amongst children and hopefully find trends that could minimize or prevent school outbreaks.

The WSLH also performed testing last year using the rapid flu testing platform being utilized in the study to verify it would work in this context.

WKOW-TV story

Wisconsin State Journal story

 

Pharmaceuticals and Personal Care Products in Lake Michigan

 

milwaukeeWSLH Environmental Health Division scientists collaborated with University of Wisconsin-Milwaukee researchers to measure levels of drugs and personal care products in Lake Michigan off the Milwaukee shoreline. It has long been assumed that the size and water volume of the Great Lakes would dilute these materials, but this research calls that into doubt.

Milwaukee Journal-Sentinel story on newest phase of this research

Interview from 2013 with WSLH Research Scientist Dr. Curt Hedman about the findings of the first phase of the research

 

Carbon Soot and the Taj Mahal

 

150120_EST-cover-photo_webThe beautiful white marble of the Taj Mahal in Agra, India has been getting dirtier over the last few decades. Researchers in India and at Georgia Tech and the WSLH Environmental Health Division have determined that carbon soot from air pollution is to blame. The next step is to determine where the contamination is coming from and what to do about it.

The answers aren’t just important for one of the most beautiful buildings in the world, but also for the many people living in the area since these types of contaminants can also cause negative health effects.

International Business Times story

Wisconsin State Journal 2012 story about the research

One Test May Not Fit All in Cervical Cancer Screening

A poster presentation looking at whether it’s better for women served by public health laboratories like the WSLH to have molecular-based HPV testing as their primary cervical cancer screening method vs. using a Pap test in combination with an HPV test won the Cytotechnologist Scientific Presentation Award at the 62nd Annual Meeting of the American Society of Cytopathology last month.

WSLH Cytology Lab Manager Erin McCarthy

WSLH Cytology Lab Manager Erin McCarthy

WSLH Cytology Laboratory Manager Erin McCarthy (pictured at left) was lead author on “Molecular Testing and Cervical Screening: Will One Test Fit All?”.  Changhong Ye, instructional program manager in the Cytotechnology Certificate program, and WSLH Medical Director Dr. Dan Kurtycz were co-authors.

Human Papillomavirus (HPV) is the primary cause of nearly all cervical cancers. Nationally, there is an increasing emphasis on using molecular HPV testing as the first-line test for cervical cancer screening. But because the women the WSLH Cytology Laboratory serves tend to be higher-risk for cervical cancer and also medically underserved, McCarthy and her colleagues wanted to know if this change in testing algorithms would be helpful or harmful.

Their research found that nearly 56% of the women determined to have high-grade cervical lesions by Pap tests performed at the WSLH ended up testing negative by molecular testing for the two most common forms of HPV responsible for cervical cancer. If only the molecular HPV tests had been used for these women, their pre-cancerous lesions would have been missed at this stage of testing.

Erin and her co-authors call into question the move toward molecular HPV testing for everyone and note that as cervical cancer screening practices evolve, it will be important to consider whether different populations of women may need different testing algorithms.

“Erin deserves an immense amount of credit for this paper,” said Dr. Kurtycz. “We are all very proud of her work in this area of public health.”

Mei Baker Receives National Newborn Screening Award

Dr. Mei Baker with her APHL award.

Dr. Mei Baker with her APHL award.

Dr. Mei Baker, Wisconsin State Laboratory of Hygiene (WSLH) Newborn Screening Laboratory co-director and University of Wisconsin associate professor of pediatrics, received the Harry Hannon Laboratory Improvement Award in Newborn Screening from the Association of Public Health Laboratories (APHL) earlier this month at the National Newborn Screening and Genetics Symposium.

The award is named after Dr. Harry Hannon, the long-time director of the Centers for Disease Control and Prevention’s newborn screening quality assurance program.

In giving her the award, APHL noted that Baker’s work has profoundly impacted and improved the current practice of newborn screening locally, regionally, nationally and internationally.

Baker, along with researchers from the Children’s Hospital of Wisconsin, led a research project that resulted in Wisconsin becoming the first place in the world to routinely screen newborns for Severe Combined Immunodeficiency (SCID), also known as “bubble boy disease”. That was in 2008, and since then Baker and the WSLH Newborn Screening staff have helped numerous states and foreign countries implement SCID testing.

Baker noted that team effort in accepting her award.

“This award is not just for me. It’s for the staff of the newborn screening lab and the newborn screening team in Wisconsin,” she said. “I’m grateful to work with such dedicated and hard-working professionals.”

SCID is just one of the 44 rare, serious inherited disorders included on Wisconsin’s newborn screening panel. These disorders are generally unrecognizable at birth and without treatment can cause severe health problems and even death. Of the nearly 65,000 babies born in Wisconsin each year, 125 to 130 will have their disorder found through newborn screening. Babies in Wisconsin are also screened for hearing loss and critical congenital heart disease in the hospital shortly after birth.

In addition to her award, Baker also recently received funding to support two newborn screening related projects.

The Legacy of Angels Foundation awarded Drs. Mei Baker and Philip Farrell nearly $590,000 to conduct a “Prospective Study of Newborn Screening for Cystic Fibrosis Using Novel IRT/Next Generation Sequencing Method”. The two-year project will evaluate the usefulness of expanded DNA analyses using a panel of 170 – 200 CFTR disease-causing mutations in newborn screening for cystic fibrosis (CF) in a real-world newborn screening laboratory environment. The hope is to reduce the number of false positive associated with CF screening.

The National Institutes of Health/National Institute of Child Health and Human Development awarded Baker and other co-investigators nearly $500,000 to conduct a project “Establishing a Newborn Screening Process for Early Identification and Treatment of Infants with Pompe Disease”. The purpose of the proposed project is to establish and evaluate a process of newborn screening for Pompe disease to facilitate early identification and treatment of infants with Pompe disease.

“We often talk about the importance of newborn screening, but I also really love what I do,” Baker reflects. “When you are able to do what you love and are recognized for it, it’s just a bonus.”

This is the second time the Harry Hannon award has come to Wisconsin. Retired WSLH Newborn Screening Lab Director Gary Hoffman received it in 2008.

The comprehensive Wisconsin Newborn Screening Program is administered by the Wisconsin Department of Health Services and the Wisconsin State Laboratory of Hygiene. The program also includes physician consultants, genetic counselors and nutrition professionals from around the state.