Translocations – Part 2

 

Abnormal chromosome is on the right in each pair

Abnormality

(major breakpoint or breakpoint range)

Disorder

Genes Involved

(Linked to NCBI)

dicentric translocation 9/20 dicentric translocation 9/20 dic(9;20)(p11-13;q11.2) ALL

PAX5 /

ASXL1

NOL4L

KIF3B

translocation 9p/11q translocation 9p/11q
t(9;11)(p21-22;q23)
dicentric translocation 9/12 dicentric translocation 9/12 dic(9;12)(p13;p13) ALL

PAX5

ETV6 (TEL)

translocation 9p/14q translocation 9p/14q t(9;14)(p13;q32) NHL, MM, CLL

PAX5

IGH@

translocation 9q/22q translocation 9q/22q t(9;22)(q34;q11.2) CLL, CML, AML

ABL1

BCR

translocation 10p/11q translocation 10p/11q t(10;11)(p11-15;q13-23) AML

MLLT10 (AF10)

KMT2A (MLL)

translocation 10p/11q translocation 10p/11q t(10;11)(p13;q21) T-ALL

MLLT10 (AF10)

PICALM

translocation 11p/14q translocation 11p/14q t(11;14)(p13-15;q11.2) ALL

LMO2 (RBTN2)

TRA@

translocation 11q/14q translocation 11q/14q t(11;14)(q13;q32) CLL, NHL, MM,
mantle cell lymphoma

CCND1

IGH@

translocation 11q/17q translocation 11q/17q t(11;17)(q23;q21) AML

ZBTB16

RARA

translocation 11q/17q translocation 11q/17q t(11;17)(q23;q25) AML, MDS, ALL

KMT2A (MLL)

SEPT9

translocation 11q/19p translocation 11q/19p t(11;19)(q23;p13.1) AML

KMT2A (MLL)

ELL

translocation 11q/19p translocation 11q/19p t(11;19)(q23;p13.3) ALL, AML

KMT2A (MLL)

MLLT1 (ENL)

translocation 11q/22q translocation 11q/22q t(11;22)(q24;q12) Askin’s tumor,
Ewing’s sarcoma, esthesioneuroblastoma

FLI1

EWSR1

translocation 12q/16p translocation 12q/16p t(12;16)(q13;p11.2) Angiomatoid fibrous histiocytoma,
myxoid liposarcoma

DDIT3 (CHOP)

FUS

translocation 12p/17q t(12;17)(p13;q21) ALL

?

?

translocation 14q/16q translocation 14q/16q t(14;16)(q32;q23) MM

IGH@

MAF

translocation 14q/18q translocation 14q/18q t(14;18)(q32;q21.3) ALL, CLL
follicular or diffuse B-cell
non-Hodgkin’s lymphoma

IGH@

BCL2

translocation 14q/19q translocation 14q/19q t(14;19)(q32;q13.2) CLL, B-cell non-Hodgkin’s lymphoma

IGH@

BCL3

translocation 14q/22q translocation 14q/22q t(14;22)(q32;q11.2) ALL IGH@

translocation 15q/17q translocation 15q/17q t(15;17)(q24;q21) AML

PML

RARA

translocation 16q/16p translocation 16q/16p t(16;16)(p13.1;q22) [variant of inv(16)] AML, MDS

MYH11

CBFB

translocation 16q/17p translocation 16q/17p t(16;17)(q21;p13) Aneurysmal bone cyst

CDH11

USP6

translocation 18q/22q translocation 18q/22q t(18;22)(q21.3;q11.2) B-cell NHL [variant of t(14;18)]

BCL2

IGL@

translocation Xp/18q* translocation Xp/18q t(X;18)(p11.2;q11.2) Synovial sarcoma

SSX1 SSX2 /

SS18

* In some cases, derivative chromosomes had to be used from unbalanced translocations. Go to Translocations–Part 1

Deletions | Inversions/Isochromosomes | Translocations 1 | Translocations 2

 

University of Wisconsin Cytogenetic Services